PHAR presented research on transthyretin-mediated (ATTR) amyloidosis and Huntington’s disease (HD) at the virtual 2021 Annual Meeting of the American Academy of Neurology. PHAR’s Sheila Reiss Reddy, PhD, RPh, Eunice Chang, PhD, and Marian Tarbox, MPP, in partnership with Akcea Therapeutics, Inc., investigated the feasibility of estimating ATTR amyloidosis prevalence and incidence using IBM® MarketScan® Commercial and Medicare databases. They also presented research on the clinical characteristics and resource use patterns among Medicare beneficiaries with ATTR amyloidosis in the years before diagnosis. In addition, PHAR’s Sheila Reiss Reddy, PhD, RPh, and Eunice Chang, PhD, in partnership with Genentech, Inc., presented their findings on healthcare resource use among US Medicare beneficiaries with late-onset HD. The posters for these studies can be found on the PHAR publications page, and the abstracts were published in Neurology’s April 2021 supplement issue.
PHAR’s Sheila Reiss Reddy, PhD, RPh, and Eunice Chang, PhD, in collaboration with GRAIL, analyzed 2012-2016 data from the linked SEER registry-Medicare claims database calculating and comparing the cancer-related costs of 17 cancers by stage of diagnosis. Their findings show patients diagnosed at later stages of cancer have higher costs of care (up to 7 times as much) than those diagnosed at earlier stages. Earlier cancer diagnosis may lead to more efficient treatment and decreased management cost. A poster detailing the findings was presented at the Annual Conference of the Hematology/Oncology Pharmacy Association and can be viewed here, and the abstract was published in the March 2021 special feature issue of the Journal of Hematology/Oncology Pharmacy.
PHAR’s Sheila Reiss Reddy, PhD, RPh, Eunice Chang, PhD, and Caleb Paydar, BS, in conjunction with Genentech, Inc., presented the results of two studies of Huntington’s disease in Medicaid beneficiaries. Their first study compared healthcare utilization and costs among US Medicaid beneficiaries with Huntington’s disease to those without Huntington’s disease. They also presented a study on the burden of illness among US Medicare beneficiaries with late-onset Huntington’s disease. The abstracts were published in the April 2021 supplement issue of the Journal of Managed Care & Specialty Pharmacy, and the posters can be found on the PHAR publications page.
Michael S. Broder, MD, MSHS, president of PHAR shares 5 numbers that will affect the pharmaceutical industry in 2021. Published on the HealthEconomics.com blog, his predictions span important domains such as COVID, politics, and future directions for health economics research. Read the post here, and reach out to let us know your thoughts.
Clinical guidance from a PHAR research study on how to taper thrombopoietin receptor agonists (TPO-RAs) in immune thrombocytopenia (ITP) was presented at the 2020 American Society of Hematology Annual Meeting & Exposition. PHAR developed this important guidance with clinical experts using the RAND/UCLA modified Delphi panel process. The consensus statements presented could serve as a guide for clinical care by identifying patients who could safely taper and discontinue TPO-RAs and help to inform the design and development of future clinical trials. The study was also published in the December 2020 issue of Research and Practice in Thrombosis and Haemostasis. The presentation and manuscript can be found on our publications page.
Michael S. Broder, MD, MSHS, president at PHAR, wrote a post for HealthEconomics.com about how health economics and outcomes researchers can help defeat COVID-19. He pointed out the important role that HEOR professionals have in not being silent about facts related to COVID-19 and in helping lay people find reliable data sources instead of wading through misinformation. He stressed that health economics and outcomes researchers can help stop the pandemic and save lives by simply stopping misinformation from spreading and sharing facts instead. The post can be found here.
Since its establishment in 2004, PHAR has collaborated with many partners in academia and industry on a numerous number of studies. These studies have resulted in over 750 publications, covering nearly 100 different products, 90 health conditions, and more than 30 data sources, and appearing in more than 200 different journals and conferences. PHAR has compiled the publications into an interactive bibliography book titled, Health Services Research Insights. The bibliography book is organized thematically, with each of four main sections devoted to a different broad area of HEOR, then further broken down by type and clinical specialty. The book is available for download now here.
Results from a study done in partnership with Akcea Pharmaceuticals and focusing on the patient journey of patients newly diagnosed with hereditary transthyretin (ATTRv) amyloidosis have been presented at multiple virtual conferences this year, including the XVII International Symposium on Amyloidosis, the European Society of Cardiology’s HFA Discoveries platform, and the Heart Failure Society of America’s Annual Scientific Meeting. This is the first real-world study to examine pre-diagnostic characteristics and healthcare utilization in this population of patients. Using commercial claims data, PHAR and Akcea found that patients with ATTRv amyloidosis experience substantial comorbidity, testing, and hospitalization prior to diagnosis. These patients also face considerable cardiovascular burden in the 5 years preceding diagnosis. These posters can be found on the PHAR publications page. A manuscript further detailing this study is currently planned for publication in a peer-reviewed journal later this year.
Two secondary data analysis studies conducted by PHAR, in partnership with Genentech, Inc, were presented at MDS Virtual Congress 2020. The first study investigated healthcare utilization and costs in Medicare beneficiaries with Huntington’s disease at the end-of-life. This study showed most beneficiaries at the end-of-life had late-stage disease and healthcare utilization and costs were greater in the last three months of life compared to the three months prior. The second study investigated the epidemiology of Huntington’s disease among Medicaid beneficiaries. This study showed that the prevalence of Huntington’s disease in the Medicaid population is higher than previously reported in other populations. The posters for these studies can be found on the PHAR publications page.