PHAR’s Sarah Gibbs and Michael Broder, in collaboration with Novartis Pharmaceuticals, organized an expert panel to develop guidelines for PIK3CA-related overgrowth spectrum (PROS) severity classification, testing, and medical management. Results were presented at the CLOVES Syndrome Community International Scientific Meeting for PIK3CA Related Conditions and can be read here.
PHAR, with support from Takeda Pharmaceuticals, produced a Monte Carlo simulation model of projected mean costs for treating patients with moderate to severe ulcerative colitis with either vedolizumab or adalimumab. The investigation found that mean estimated total costs per patient treated with either therapy over 1 year were $14,322 lower for vedolizumab than for adalimumab, which may help to inform formulary decision-making. Jesse Ortendahl, Director of Health Economics at PHAR, presented the findings at the American College of Gastroenterology’s Annual Scientific Meeting & Postgraduate Course. See the poster here, and the abstract published in the October supplement issue of the American Journal of Gastroenterology.
Michael Broder, MD, MSHS, President of PHAR, along with Jesse Ortendahl, Director of Health Economics at PHAR, recently spoke at Evidence Matters ’21, a virtual summit for the literature review community. At the meeting, they joined Dr. Patti Peeples of HealthEconomics.com in a session titled “Applying Systematic Reviews to Real-World Evidence Study Design.” The session highlighted how the increase in publications using real-world data impacts systematic literature reviews, along with the use of real-world evidence in other areas such as economic modeling.
Research conducted by PHAR and supported by Amgen was presented in the poster sessions at AMCP Nexus in Denver, CO. PHAR’s claims analysis on psoriatic arthritis (PsA) patients compared biologic initiation risk in systematic-naïve PsA adult patients using apremilast versus methotrexate, building on research previously presented at AMCP 2021 and AAD VMX. The investigators’ findings suggest that patients who initiate apremilast are more adherent and have a lower likelihood of biologic initiation when compared with patients initiating methotrexate. In patients who do need biologics, time to biologic initiation is longer in apremilast users than in methotrexate users. The poster can be viewed on PHAR’s publications page and the abstract was published in the October supplement issue of AMCP’s Journal of Managed Care & Specialty Pharmacy (JMCP).
Two studies conducted by PHAR were presented at the 37th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS). The first study, done in partnership with Sanofi US, examined the effectiveness of teriflunomide in patients with relapsing multiple sclerosis (RMS) who switched from other DMTs following disease progression. The authors of this retrospective chart review study observed that RMS patients who switched to teriflunomide after progression may have experienced reductions in EDSS scores and stable or reduced relapse rates. In the second study, PHAR collaborated with Genentech to develop a claims-based algorithm to identify patients with neuromyelitis optica spectrum disorder (NMOSD) and distinguish them from patients with multiple sclerosis and other central nervous system inflammatory disorders, allowing researchers and clinicians to better estimate NMOSD burden. The posters can be viewed on the PHAR website publications page and the abstracts were published in the October supplement issue of Multiple Sclerosis Journal.
PHAR’s President Michael S. Broder, MD, MSHS, and Director of Health Economics, Jesse Ortendahl, appeared at a roundtable hosted by Evidence Partners and HealthEconomics.com to address questions around how to best automate systematic reviews. With the increasing number of scientific journals over the last few years, using the most effective and up-to-date methods for conducting literature reviews has become a must. Michael and Jesse shared best practices learned conducting systematic reviews over two decades. The pair will also be presenting at EP’s upcoming Evidence Matters ’21.
PHAR, with support from Dompé US, Inc., published their synthesis of clinical recommendations for the management of neurotrophic keratopathy (NK), an uncommon, underdiagnosed degenerative corneal disease, in BMC Ophthalmology. The investigators gathered an 11-member expert panel who reviewed published evidence and independently rated 735 patient scenarios using a validated methodology (a RAND/UCLA modified Delphi panel) to develop consensus on when to screen for and how best to diagnose and treat NK. Diagnosis may be delayed in NK because patients experience few symptoms, however, the best opportunity to reverse ocular surface damage and prevent progression is early in the disease course.
Michael S. Broder, MD, MSHS, President at PHAR, and Jesse Ortendahl, Director of Health Economics at PHAR, discuss the inherent racial equity problem in cost-effectiveness analysis and how the history of racial injustice in health outcomes can be unintentionally perpetuated by researchers. Read their post at HealthEconomics.com here.
PHAR’s David Beenhouwer, MD, Michael S. Broder, MD, MSHS, Sarah N. Gibbs, MPH, and Irina Yermilov, MD, MPH, in collaboration with Novartis Pharmaceuticals, organized a multidisciplinary panel of practicing emergency department (ED) clinicians and used the modified Delphi panel process to develop an order set for managing acute pain in sickle cell disease (SCD) patients in the ED. Painful, incapacitating vaso-occlusive episodes (VOEs) are a hallmark of SCD. Recommended treatment within 30 minutes of triage is rarely achieved in clinical practice; ED order sets may facilitate better VOE management. The description of the process and resulting order set was published in the Journal of the American College of Emergency Physicians Open and can be read here. The resulting order set is presently undergoing review, adoption, and implementation in several NYC EDs.
PHAR’s Sheila Reiss Reddy, PhD, RPh, Eunice Chang, PhD, and Marian Tarbox, MPP worked with collaborators at Akcea Therapeutics, Inc., to conduct a retrospective analysis using Medicare claims data to identify cardiovascular conditions within 3 years prior to a transthyretin amyloidosis (ATTR) diagnosis. Findings show Medicare beneficiaries with ATTR have considerable cardiovascular conditions prior to diagnosis. Awareness of characteristic cardiovascular symptoms could lead to earlier diagnosis and prompt intervention. Results were presented as a poster at the virtual Heart Failure Congress 2021, and can be viewed here.