Investigators at PHAR, LLC and Genentech, Inc. conducted research that was presented at the American College of Allergy, Asthma & Immunology 2011 Annual Scientific Meeting. Researchers found that the number of chronic conditions and respiratory comorbidities predicted adherence and persistence to omalizumab therapy.

Cost-effectiveness techniques can provide valuable insight into breast cancer treatment. A recent PHAR, LLC study assessed the impact on health outcomes and healthcare expenditures of adopting a 21-gene assay for women with early-stage, minimally node-positive, estrogen receptor-positive HER2-negative breast cancer. The study found that the use of this 21-gene assay was associated with improved outcomes for these breast cancer patients, with no additional cost. To see the publication in its entirety, visit The American Journal of Managed Care website.

Four posters presenting research conducted by PHAR, LLC in collaboration with Eisai Inc. were featured at the Multinational Association of Supportive Care in Cancer 2011 International Symposium in Athens, Greece. Investigators examined the risks of chemotherapy-induced nausea and vomiting (CINV) following the use of several chemotherapy regimens and the costs associated with CINV.

PHAR investigators used nine health-related quality of life (HRQoL) measures to study how HRQoL varies by body mass index category among gender and racial subgroups. The research found that a lower HRQoL score was associated with being obese or overweight rather than with having a normal body mass index. The associations were driven primarily by physical health. The degree of the associations varied by the index used. PHAR, LLC investigators collaborated with the RAND Corporation, University of Wisconsin-Madison School of Medicine and Public Health, UCLA School of Public Health, Kaiser Permanente Northwest Region, and Health Utilities Inc. For more detailed results, visit the Quality of Life Research website.

Using a retrospective cohort analysis, PHAR, LLC investigators collaborated with researchers at the University of Michigan and Genentech, Inc. to study adherence to Pulmozyme® in patients with cystic fibrosis. The findings were presented at the 34th European Cystic Fibrosis Society Conference.

Investigators at PHAR, LLC evaluated the economic impact of alvimopan in clinical practice. They found that, along with other initiatives to improve quality and reduce costs of surgical care, alvimopan may be a good choice for use in the perioperative management of patients who undergo segmental bowel resection. This research was published in the P & T journal.

A recent PHAR, LLC study evaluated treatment recommendations for patients with lymph node-positive, estrogen receptor-positive breast cancer. Specifically, investigators sought to determine the effect of the 21-gene recurrence score (RS) assay results on physician decision making for such patients. The findings show that the RS result was used in determining treatment more often when patients had tumors less than 5 cm and one to three positive lymph nodes than when tumors were larger and patients had four or more positive nodes. Use of the RS also resulted in an overall reduction in recommendations for chemotherapy. This research was published in the Journal of Oncology Practice.

In an era of ever-increasing healthcare costs, knowledge of cost effectiveness is critical for US physicians, policymakers, and payers alike. Results from a cost-effectiveness study undertaken by investigators from PHAR, LLC and Bristol-Myers Squibb was presented at the 10th International Congress on Drug Therapy in HIV Infection. The model found that patients using atazanavir with ritonavir experience AIDS diagnoses, opportunistic infections, coronary heart disease events, and diarrhea episodes less often than patients using lopinavir in combination with ritonavir.

Two posters detailing findings from a systematic literature review were presented at the International Society for Pharmacoeconomics 14th Annual European Congress. The systematic review examined the impact of skeletal-related events on pain, quality of life, morbidity, survival, and cost in patients with prostate and breast cancer. The report was created by PHAR, LLC researchers in collaboration with researchers at Bristol-Myers Squibb.

PHAR, LLC presented research on schizophrenia management at the American Psychiatric Association’s 2010 Institute on Psychiatric Services. PHAR investigators conducted a retrospective cohort study of antipsychotic therapies, and findings from this study confirmed that adherence to antipsychotic treatment is an important determinant of health service use in general and hospitalization in particular. Outcomes may be improved in patients by choosing medications whose effect is less likely to be reduced by imperfect adherence-specifically those with longer half-lives.