Five studies conducted by teams at PHAR were presented at the Academy of Managed Care Pharmacy Managed Care & Specialty Pharmacy Annual Meeting in San Francisco. These studies cover a wide range of diseases and methods including cost effectiveness study of treatments for peripheral t-cell lymphoma, an analysis of insurance claims among cystic fibrosis patients, and an examination of patients with idiopathic pulmonary fibrosis using the National Inpatient Sample. The five posters can be found here.
Presentations & Events
PHAR announced that results from the first study to assess the clinical utility of the DCIS Score Assay in management of DCIS will be presented at American Society of Clinical Oncology (ASCO) Annual Meeting. Clinicians and breast cancer patients must decide among multiple treatment options including breast conserving surgery, mastectomy, partial or whole breast radiation, and hormonal manipulation. Treatment recommendations are usually made using clinicopathologic factors to estimate average local recurrence risk for similar patients. The validated Oncotype® DX 12-gene assay for DCIS gives additional, independent, individual estimates of 10-year risk In association with 10 cancer centers throughout the United States, PHAR conducted a prospective observation study on the impact of the DCIS Score result on radiation treatment recommendations for patients with DCIS. The study results will be presented at ASCO’s 50th Annual Meeting in Chicago, IL, and can be viewed here.
Experts from Eisai presented findings of a PHAR/Eisai study on chemotherapy-induced nausea and vomiting (CINV) medication at the MASCC/ISOO International Symposium on Supportive Care in Cancer, held in Berlin, Germany. The investigators compared the cost and occurrence of CINV between patients who were only prescribed palonosetron and patients who were prescribed the generic alternative in combination with other oral medication. The study found that patients treated with palonosetron alone had a significantly lower risk of CINV, and lower CINV-related charges, than patients treated with generic alternatives. The poster can be viewed here
Researchers at PHAR, in conjunction with experts from Novartis Pharmaceuticals Corporation, presented the results of several studies on Cushing’s disease at the Endocrine Society’s 95th Annual Meeting on June 19th, 2013. Cushing’s disease, a pituitary disorder, is poorly studied because of its rarity. The PHAR research team reported on the incidence, treatment patterns, and annual economic burden associated with the disease–topics on which very little was previously known. The three posters presented at ENDO can be viewed by clicking the links below:
The PHAR researchers presented three posters at the 18th Annual International Meeting of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) in New Orleans, LA. A summary and link to each poster can be found below:
- A Markov cohort model assessed the clinical and economic trade-offs of two products (EVG/cobi/FTC/TDF and EFV/FTC/TDF) in first-line antiretroviral therapy in US adults and found that EVG/cobi/FTC/TDF was not cost effective in the base case compared with EFV/FTC/TDF for first-line HIV treatment. The poster can be viewed here.
- A comparison of healthcare costs and utilization between epilepsy patients treated with Long-Acting and Short-Acting antiepileptic drug (AED) monotherapy found that LA AED users incur a lower economic burden than SA AED. The poster can be viewed here.
- An evaluation of commercially-insured patients with Cushing’s disease, a rare disorder resulting from excessive exposure to glucocorticoids, found a substantial economic burden in these patients with up to $35,000 incurred annually in overall healthcare costs, of which $31,995 are for medical costs. The poster can be viewed here.
PHAR researchers collaborated with investigators at Eisai Inc. to evaluate the prevalence of hematologic conditions in patients with myelodysplastic syndrome (MDS). Researchers compared two MDS patient groups: patients receiving hypomethylating agents (HMAs) and patients receiving supportive care alone. The study concluded that hematologic conditions were more common in patients who received HMAs, with the most frequently observed conditions being anemia and neutropenia. A poster detailing the findings was presented at the 2012 MASCC/ISOO International Symposium on Supportive Care in Cancer. This study was published in the November/December issue of American Health & Drug Benefits and can be viewed here.
Physician experts from 10 regionally based academic practices in the US formed an expert panel with the purpose of developing a consensus on the appropriateness of medical therapies for grade 1-2 unresectable neuroendocrine tumors of the pancreas (PNETs). The panel was facilitated using the RAND/UCLA modified Delphi process, a systematic method for group decision making. The panel statements agreed with-and increased the detail of-previously published PNET guidelines. The full results of the expert panel were presented at a poster session of the 94th Annual Meeting & Expo of ENDO in Houston, Texas.
PHAR investigators along with experts from Novartis Pharmaceuticals Corporation and Stanford University School of Medicine collaborated to produce comprehensive research on acromegaly, a chronic and debilitating disorder caused by excessive growth hormone secretion. Research topics ranged from the prevalence of acromegaly complications and treatments to healthcare utilization and costs within the United States. The most common complications of acromegaly were musculoskeletal abnormalities, hypopituitarism, sleep apnea, and reproductive system abnormalities. In addition, although acromegaly is rare, annual costs are high with the risk of hospitalization being more than 50% higher in patients with sleep apnea or musculoskeletal complications and nearly three times higher in patients with cardiovascular disease than in patients without complications. Two posters were presented at the 94th Annual Meeting & Expo of ENDO in Houston, Texas, that outline the research findings.
According to the Center for Medicare & Medicaid Services, one major goal of health reform is to “lower health care costs through better health care quality.” Improved quality can take many forms-one of them is greater use of simple, low-cost, cancer screening tests, like mammograms. Researchers at PHAR, LLC, the UCLA Center for Surgical Outcomes and Quality, and RAND developed a framework to assess the cost-effectiveness of improving compliance in the US with the Healthcare Effectiveness Data and Information Set, a comprehensive set of quality indicators. The investigators found that improving quality on three cancer screening measures (cervical, breast, and colon) might save lives, but it will not save money. Results were presented at the 2012 American Society of Clinical Oncology Annual Meeting. View the abstract at the ASCO Annual Meeting website ; the poster is available for download here.
Investigators at PHAR, LLC and Genentech, Inc. conducted research that was presented at the American College of Allergy, Asthma & Immunology 2011 Annual Scientific Meeting. Researchers found that the number of chronic conditions and respiratory comorbidities predicted adherence and persistence to omalizumab therapy.