PHAR, LLC is a clinically focused health services research consultancy. We combine rigorous methodology with extensive clinical expertise to support clients in the life science industry. Our clients appreciate the unique insight our experienced staff brings to each and every project. Unencumbered by corporate bureaucracy, we can efficiently execute contracts and complete projects on time and on budget. We pride ourselves on being reliable and responsive to our clients’ changing needs.

Genomics

The sequencing of the human genome and the development of low cost microarrays have led to a proliferation of tests of gene expression in many cancers, many of which tests are designed to predict recurrence and guide treatment. Other assays guide the selection of chemotherapeutic regimens. Medicare and private payer reimbursement of these tests depends on providing evidence of 3 types of validity: analytic validity, clinical validity, and clinical utility.  PHAR, LLC has a proven track record of developing methodologically sound evidence of clinical utility for a variety of genomic tests, as well as extensive experience in developing tools to communicate these results with managed care payers.

Services relevant to the genomics industry include:

  • Prospective studies of the impact of genomic testing on treatment
  • Medical record review studies comparing pre- and post-testing recommendations
  • Comparisons of assay-based recommendations to national guidelines
  • Systematic literature reviews of clinical utility studies
  • Interactive budget impact models of the cost of genomic tests
  • Cost-effectiveness models of genomic testing compared to usual care

Health Economics

Articulating a strategy to demonstrate a product’s value requires careful consideration of the marketplace, a product’s attributes, and the competitive landscape. The health economic tactics needed to execute this strategy can be considered only after such a plan has been laid out.  Every PHAR, LLC project begins with a careful assessment of our client’s needs, the competitive landscape and the product strategy. Our combination of clinical and economic experience then allows us to bring a big picture focus to every project, regardless of size or budget.

The health economics group at PHAR, LLC uses cost effectiveness and budget impact analyses to help clients in the life sciences industry establish value for their products. Our clinically-relevant, transparent models are populated with real world data and demonstrate to payers, clinicians, and researchers the economic and health-related impact of various technologies and products.

Our health economic services include:

  • Cost-effectiveness and decision models using both Excel and TreeAge
  • Interactive budget-impact models to communicate with clinicians and payers.
  • AMCP style dossiers
  • Cost of noncompliance studies
  • Burden-of-illness studies
  • Comparative cost and utilization studies using a wide variety of advanced statistical techniques

Outcomes and Health Services Research

Understanding patterns of health care use is a core aspect of health services research. Most “patterns of care” studies focus on one or more specific care component: cost of care, quality in relation to guidelines, persistence and compliance, and drug or other health service utilization. PHAR, LLC has developed a proprietary method of graphical analysis called GRAPHx to improve the interpretability of these kinds of studies. Using patient-level, high-resolution graphics, we can create single-page images that illustrate thousands of patient histories. When combined with more traditional analyses, these graphical summaries give us deeper insight into common health care practices.

The PHAR, LLC outcomes research conducts a variety of study types, including systematic literature reviews, primary data collection with retrospective or prospective patient chart reviews, physician surveys, as well as secondary data analyses using major commercial-insurance databases and other data sources. The group disseminates study findings in a variety of forums to provide payers, clinicians, and researchers with novel and timely data on a variety of important health services research topics.

In addition to our proprietary data visualization tool, we also conduct:

  • Systematic literature reviews
  • Meta-analyses, and indirect comparisons of a wide range of clinical and economic outcomes
  • Studies of the impact of compliance and persistence on clinical and economic outcomes
  • Assessments of healthcare quality using primary and secondary data
  • Validation of claims-based algorithms for patient identification
  • Patient-reported outcome measure validation
  • Patient-reported outcome dossiers

Proprietary Software

GRAPHx

Understanding patterns of health care use is a core aspect of health services research. Most “patterns of care” studies focus on one or more specific care component: cost of care, quality in relation to guidelines, persistence and compliance, and drug or other health service utilization. PHAR, LLC has developed a proprietary method of graphical analysis called GRAPHx to improve the interpretability of these kinds of studies. Using patient-level, high-resolution graphics, we can create single-page images that illustrate thousands of patient histories. When combined with more traditional analyses, these graphical summaries give us deeper insight into common health care practices.

GRAPHx can:

  • Illustrate prescription trends over time
  • Explain patterns of use of complex drug regimens
  • Provide high-level insights into market dynamics
  • Highlight patterns of medication compliance and persistence

 

Nationwide Inpatient Sample Explorer

The Nationwide Inpatient Sample (NIS) is the largest public all-payer inpatient care database in the US, covering over 8 million stays per year in 1051 hospitals located in 45 states. The underlying data are robust and nationally representative, but conduct analyses using this data source can be complicated and expensive. Our web-based, interactive tool allows anyone to conduct comparative analyses in the NIS with ease.

With the NIS Explorer, the end user can:

  • Analyze inpatient trends over time
  • Explore charges from all payers
  • Compare length of stay and cost for different conditions
  • Conduct complex, multivariate analyses with one click
  • Get results in real time or delivered to your inbox

Strategic Consulting/Expert Panels

Using a well tested, rigorous method can help organizations draw on expert advisors to formulate strategy. A quantitative method, called the Delphi process, improves information gathering and decision making. This method was described in Harvard Business Review as a way to develop “highly useful strategic guidelines.” We have used it to help companies determine whether new clinical trials are likely to be worth their cost; to determine the direction of marketing campaigns; to develop classification systems and terminology for common diseases; to develop appropriateness of various treatments for a particular type of patient; and to set standards for economic analyses. In such situations, traditional processes for problem solving had not been fruitful, but the Delphi panel method was able to produce meaningful results.

Click here to download a detailed description of the Delphi process.

Other strategic consulting services include:

  • Advisory boards
  • Strategic plan development
  • Consulting services
  • Competitive message evaluation
  • Publication planning and implementation
  • Value proposition development